Get a Porter's X2 Ray Gun, its AMAZING!
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ray gun obv the penetrator is good too I think it's the WunderWaffe DG-2.
You can kill him, get a scavenger and a ray gun, pack a punch the scavenger and shoot him in the head with it and if you run out of ammo from the scavenger us the ray gun and hell die, Make sure you do this when there is a slow crawler and your on the island where George gets out in the beginning of the game.
If you get the VR-11 (The Human Gun) in the mystery box, upgrade it in the Pack-a-Punch. Then find George and lead to the any water area, and shoot him in the water with your Pack-a-Punched VR-11. It will do it in one shot if you hit him. You can also kill him with bullet weapons in and out of water. The best way is to get the scavenger and/or ray gun, use up all your ammo on him, then Pack-a-Punch it and finish him off. Shotguns are also very effective against George.
It is gone. When you go back it won't be there anymore.
you can only go to the pack a punch room when the rocket lauckes then under where the rocket was is the pack a punch room