In the movie Sophie's choice Sophie must choose to save her son or her daughter, therefore, "Sophie's Choice" is the most difficult choice one must make
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You can find the Mean Girls script here: http://www.hollywoodscriptshop.com/mean_girls_script.html
It means off screen.
In real life, all of the wrestlers are friends. But in the script, they are basically enemies. But most wrestlers are friends with each other in real life.
Those number(s) indicate the page in the script that the character first appears on. They put them there so that you don't have to go searching through the whole script for the character. However, most times, when you get a breakdown from a talent agent (or casting director if an open call), they only provide the portion of the script that you need for the role you are auditioning for (these script segments are called "casting sides" or just "sides"). Rarely do you get the whole script, but it does happen on occasion.
Om mani padme hum, which is a Buddhist mantra, something like "hail the jewel in the lotus."