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Long-term use of thyroxine, a synthetic form of the thyroid hormone, is generally safe and effective for managing hypothyroidism. However, potential side effects may include osteoporosis due to increased bone turnover, cardiovascular issues such as arrhythmias, and the risk of developing hyperthyroid symptoms if dosages are too high. Regular monitoring of thyroid hormone levels is essential to ensure appropriate dosing and minimize risks. Additionally, some patients may experience psychological effects, like anxiety or mood changes, particularly if hormone levels fluctuate.
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