It is very simple Go to Jubilife City and go on your bike. Put it on a fast gear an ride around till it gets close. You have four routes to find it. Most common spot is route 218 (The route between Jubilife and Canalave). It should take 2-15 Minutes. If it is taking longer. Than you have probably screwed. And don't forget to use a max repel to only encounter Mesprit and not some wild Pokemon. Hope it helps!
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The best fishing spot on Pokemon diamond is the 3 lakes where u can also find mesprit uxie and azelf
When you kill any legendary Pokemon (Mesprit included), you will not be able to catch it again. It will be gone forever. That iis why it is best to save before you battle a legendary.
to catch mesprit in pokemon platinum go to its cave(after beating team galatic and catching/defeating girantina)at lake verity use surf and swim to the cave in the middle. talk to mesprit and it will run away and oak will tell you after it and use your marking map to track it down. best strategy to catch it is get a pokemon with a move like mean look or make it go to sleep. also mesprit is level 50 like uxie and azelf
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