It is possible It depends on the size of the pellet and where you hit the squirrel. A hunting pellet is best to use when hunting squirrels they are designed to flatten out when they strike. Pointed pellets might go right through the rodent. Never use BB's to shoot a squirrel. The BB doesn't deform and can cause great agony for the critter before it kills it. It's always best to try for a head shot.
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