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NO!!! There ARE some firearms that are made to fire both, but the standard .410 shotgun is not. You are trying to push a .45 caliber bullet through a .41 caliber barrel. This is extremely dangerous. Can it be done? Yes. How many times can it be done before you blow the gun up? No one knows THAT answer!

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Q: Can any 410 shot gun shoot 45 colt rounds?
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