Can you take a ssri and tricyclic together?

Answer 1

Generally doctors avoid SSRI and TCA combinations. Safer approaches are tried first, as switching to different agents, increasing dosages, SNRIs (Effexor and Cymbalta), combinations of SSRI and Wellbutrin, Remeron or buspirone (Buspar) or augmentation of the SSRI with modafinil (US: Provigil).

Well, if these didn't help you, you can try SSRI + TCA but expect some side effects that may be irritating. Most common from this combination should be dry mouth, constipation, weight gain, and of course sexual side effects.

If you have especially high anxiety, your doctor most certainly will prefer the use of SSRI + TCA from some of the above solutions.