Nobody is sure. According to one's opinion it's most likely not going to happen because there has been 2 other girls that took her place for a while. They probably took her out because the actor had to go some place, couldn't do it any more or quit.
Another opinion believes that Misty won't return because Ash is currently traveling with Cilan and Iris so they believe original traveling companions such as Misty won't return.
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No it will not come back because it's a legendary Pokemon and there's only one of themActually it does come back. You have to wait a week and he will be there again to battle you.ACTUALLY, THE POKEMON DOES NOT COMEBACK UNLESS YOU RESTART YOUR GAME.
It will not come back.
it depents of witch Pokemon game you means...
It wont come back unless you saved before you battled it.
no