the best weapon will be thunder gun, ray gun, stakeout, and more. Any one of these u can kill them 1-2 shot kill.
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There combat level is usually 122 or 127 link to wiki hellhound: http://runescape.wikia.com/wiki/Hellhound
That really depends on your slayer level, as well as on your combat level. The higher-level slayer masters will give you more difficult monsters to slay.
Here's a few places where you'll find Hellhounds: - God Wars Dungeon ( Level 127 - Max Hit 14) P.S wear Zamorak cape ( mage arena ) to avoid being teamed. - Taverly Dungeon ( Level 122 - Max Hit 13 ) - South Of Taverly - South Of Axe Hut - Members Wilderness - Eastern Ardougne Dungeon - Wilderness Volcano (the only site in free-play)
there is no best way there is only your way.
say, sway, spray, stay, sexy, slay, spry, spay