Piccolo, though some percussion instruments can be smaller.
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The right answer is Mandolin
In a string orchestra, the instrument with the lowest pitch is the Bass (also called Double Bass, String Bass, Upright Bass, and Contrabass)
The London Symphony Orchestra
The violins are the ones usually with the melody
Do you mean within the plot lines of the episodes? If so, just about every instrument that exists since full orchestras have been represented in at least 2 episodes. If you mean instruments that compose the music for the show, it's the same answer. Family Guy uses a 60 piece orchestra to perform the music.