naruto doesnt ever become the 6th hokage because an akasuki member call pain destroyed the village and the 5th hokage tride to save every body and ran out of chakra then went into a coma so some guy called danzou was elected hokage so naruto will be either the 7th or 8th hokage
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She becomes the fifth hokage.
Tsunade wakes up in episode 219 just when Kakashi Hatake is about to become the sixth hokage.
She has called Tsunade: Tsunade-sama (Lady Tsunade), Hokage-sama, Godaime Hokage-sama (5th Hokage), and Shishou. (master)
because technically she is kined to Naruto because Mito Uzumaki is Tsunade's grandmother
=No, but naruto calls her grandma tsunade just to annoy her.=