Tsunade wakes up in episode 219 just when Kakashi Hatake is about to become the sixth hokage.
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Tsunade Going to wake up just as kakkashi is about to Be the six hokage but as she has woke up kakkashi does not need to be hokage and tsunade is still the 5th hokage. Then the others hokage holds hokage summit where tsunade gets filled in whats happening and at the hokage summit she agrees to send naruto away for his his own safety.
Whilst Naruto is fighting Pain, Tsunade gets knocked into a coma for she has reduced almost all her chakra. Naruto then defeats Pain then Danzou becomes Hokage until he dies by Sasuke then Tsunade wakes up and becomes Hokage again.
She has called Tsunade: Tsunade-sama (Lady Tsunade), Hokage-sama, Godaime Hokage-sama (5th Hokage), and Shishou. (master)
she used up too much of her chakra healing ALL the survivors from Peins attack. it took everything out ov her so she went into her state of coma
Tsunade doesn't bounce.
It is impossible to wake up dead, because if you were dead, you wouldn't wake up. If you wake up, then you are not dead. You cannot wake up dead, though. No, if you go to bed alive then you would have to be in the bed dead so you would have to wake up dead. Haven't you ever seen scary movie 3?
Tsunade because sakura is still in training but there are hints that say that once shes older she will be the new tsunade if not stronger