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Yess she wakes up in naruto manga 488 you can see it at onemanga.com shizune and a medicle guy was crying she woke up shizune hug her and tsunade said that hurts they inform the 2 elders and kakashi right in the middle of kakashi being selected to be new hokage

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episode 219

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Q: What episode of naruto shippuden does tsunade wake up?
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