She was killed in the Great Jedi Purge in 19 BBY. See Wookieepedia for more info.
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She was killed by clones by being shot through the stomach or chest.
No. Aayla is a Twi'lek and Shaak Ti is a Togruta, so they can't be sisters. But they are among the most well-known female Jedi and are some of the best
Barriss Offee got killed on felucia helping aayla secura during order 66. On the movie you don't see her with aalya secura but if you read the comics you do. Barriss Offee is on another part of the planet with some clones when emperor palpatine orders the clones to kill her. Barriss Offee dies from a shot from an at-te walker blaster cannon. Just like obi-wan on utapau but she dies and he doesn't.
She was shot in the the back by the clones.