Yes. From making up the characters-to finishing the inking. I'm making one myself currently. But you need special materials.
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Anime doesnt neccesarily use the ratings scale but for your question anime that 'would' be rated 18 above is any ecchi or hentai anime.
actually, there is no episode about Yotsuba there is only the books. Creator of Yotsuba is making Show for azumanga daioh.
Grow your hair out and bleach it white. Get contacts with yellow lenses and slit pupils. Buy a red hakama and haori. Wear fake fangs.
Anime, anime, everythang anime, bag anime, watch anime.. And it goes on and on.
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