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I don't think anyone's done enough research on it yet to know exactly why, but this is a real thing: chronic marijuana users sometimes exhibit what doctors like to call "hyperemesis" (because "puking all over the place" doesn't sound formal enough).

One theory goes something like this:

  1. Marijuana gives people the "munchies".
  2. There's an indigenous (naturally occuring) cannabinoid system in the body that marijuana is probably "hijacking" to produce this effect.
  3. If you use a lot of marijuana for a long time, the natural system throttles back.
  4. Since your natural system is now underperforming, your digestive system goes wonky and you throw up a lot.
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Q: Why does marijuana make you sick?
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