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Depends on what you mean by "powerful", commercial or wildcat cartridge, current or obsolete? Rifle or handgun? Does it have to be of a bigger diameter or just deliver more ft/lbs of energy or do you just want to know about velocity? Rimfire or centerfire?

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Q: What is the next powerful gun from a 22?
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What is the name of the gun that has a shot gun and 22?

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