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Rabeprazole sodium is the newest member of a class of substituted benzimidazole molecules known as proton pump inhibitors. Other proton pump inhibitors have been shown to be effective in healing active, benign gastric ulcers.
Methods: In this randomized, double-blind, multicentrestudy, conducted at 25 European sites, rabeprazole and
omeprazole were compared in patients with active gastric ulcers. Two hundred and twenty-seven patients with active benign gastric ulcer were randomized to receive either rabeprazole 20 mg (nà 113) or omeprazole 20 mg (nà 114) once daily for 3 or 6 weeks, with healing monitored by endoscopy. Results : After 3 weeks, complete healing (ITT analysis) was documented in 58% of patients given rabeprazole and 61% in patients given omeprazole (N.S.). After 6 weeks the healing rates were identical in both groups at 91%. Rabeprazole-treated patients had numerically greater symptom relief at all 12 points of comparison. The differences significantly favoured rabeprazole at week 3 for daytime pain improvement (P= 0.023) and at week 6 for pain frequency (P= 0.006) and complete resolution of night pain (P= 0.022). Both drugs were well-tolerated over the 6-week treatment course. Mean changes from baseline to end-point in fasting serumgastrin were comparable. No significant differences in laboratory parameters were seen.
Conclusion: In this study, rabeprazole produced healing rates comparable to omeprazole at weeks 3 and 6, but provided more consistent and occasionally significantly superior symptom improvement. Both treatments were well-tolerated.
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LaoOmeprazole and rabeprazole are both proton pump inhibitors used to treat conditions related to excess stomach acid. The main difference is their chemical structure, which can affect how they are metabolized in the body and their potency. Rabeprazole may be more effective for some individuals, but both drugs are generally well tolerated and have similar side effects.
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What is the difference between Pantoprazole and rabeprazole?
Pantoprazole and rabeprazole are both proton pump inhibitors used to reduce stomach acid production. They have different chemical structures and slightly different mechanisms of action, but they are both effective in treating conditions such as acid reflux and ulcers. The choice between the two drugs is typically based on individual patient response and tolerability.
What is the difference between Omeprazole and Omeprazole Magnesium?
Omeprazole is the active ingredient, while Omeprazole Magnesium is a compound of omeprazole with magnesium. Omeprazole Magnesium may be easier on the stomach due to the presence of magnesium, but the effectiveness in treating acid-related conditions is generally the same as regular omeprazole.
Does omeprazole contain iron or calcium?
Omeprazole does not contain iron or calcium as its active ingredient is omeprazole magnesium. However, some formulations of omeprazole may contain inactive ingredients that include calcium or iron as fillers or coatings. It is important to check the specific formulation of omeprazole you are taking if you have concerns about these ingredients.
Does omeprazole contain sulfur?
No, omeprazole does not contain sulfur as an active ingredient. It is a proton pump inhibitor used to reduce stomach acid production.
What is the dissolution medium for Rabeprazole enteric coated Tablet?
The dissolution medium commonly used for testing Rabeprazole enteric-coated tablets is acidic buffer solutions such as Simulated Gastric Fluid (SGF) with a pH of 1.2 for the initial stage and then transitioning to Simulated Intestinal Fluid (SIF) at pH 6.8 to simulate conditions in the stomach and intestines, respectively. These buffers help to mimic the pH conditions the tablet will encounter in the gastrointestinal tract and assess its release characteristics.
