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What is the difference between Betahistine hydrochloride and Betahistine dihydrochloride?
Betahistine
Betahistine hydrochloride is the generic name for the anti vertigo drug SERC. It was first registered in Europe in 1970 for the treatment of Ménière's disease. It is commonly prescribed for people who have balance disorders or to alleviate the vertigo symptoms associated with Ménière's disease.
Betahistine is available in 8mg or 16mg tablets taken 3 times daily. Doses may be adjusted to between 24-48mg a day as needed. It is contraindicated for people with peptic stomach ulcers or tumours of the adrenal gland. People with bronchial Asthma should be closely monitored.
Chemistry and Pharmacokinetics
Betahistine chemically is 2-[2-(methylamino) ethyl] pyridine, and is formulated as the dihydrochloride salt. Is is as close resembling between the structures of betahistine and histamine.
Betahistine comes in a tablet form and should be taken orally. It is rapidly and completely absorbed from its tablet form. The mean plasma half-life is 3-4 hours, and excretion is virtually complete in the urine within 24 hours. Plasma protein binding is very low.
The metabolism of betahistine produced two inactive metabolites, pyriylacetic acid and 2-(2-aminoethyl) pyridine.
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CoachBetahistine hydrochloride and Betahistine dihydrochloride are salt forms of the same drug, betahistine. The difference lies in the chemical composition of the salts, with hydrochloride containing one hydrochloride ion per molecule and dihydrochloride containing two hydrochloride ions per molecule. Both forms are used to treat vertigo and Meniere's disease.
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