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Actually they are the same substance. A chloride ion is introduced to amantadine to become amantadine hydrochloride. This will be helpful to increase the solubility of amantadine. Most drugs are absorbed faster by the body if they are salts, especially hydrochloride salts and sulfate salts

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Q: What is the difference between Amantadine and Amantadine hydrochloride?
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