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The .22 magnum is more powerful, longer and a larger diameter than the .22lr. The magnumcartridge does not use the "heel seated" bullet of the .22 LR, and USUALLY has jacketed bullets. The full name is .22 WMRF (Winchester magnum rim fire) and they do NOT interchange with .22 LR. There have been a few revolvers built with two different cylinders to permit switching between LR and Magnum.
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