What is substance dependence?

Answer 1

A maladaptive pattern of use of alcohol, drugs, or other substances, with tolerance and/or withdrawal symptoms, drug-seeking behavior, and lack of success in discontinuation of use, to the detriment of social, interpersonal, and occupational activities.

Answer 2

Substance abuse is the continued compulsive use of mind-altering substances despite personal, social, and/or physical problems caused by the substance use. Abuse may lead to dependence, in which increased amounts are needed