It means hes dated lots of girls but all of them werent right for him, they were probably all mean and snobby. But your different from those other girls, your actually the girl for him.
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When a guy says you're different from other girls, it could mean he sees unique qualities in you that stand out from his past experiences. He may appreciate your individuality, personality, or values that distinguish you from others he has met. It could be a compliment showing he finds you special or intriguing in a positive way.