Assuming you are not a lesbian and are asking how to make sure she doe not make a move on you, tell her that you are okay with her decision to be a lesbian, but don't make any moves on you. Tell her you still want to be friends but you don't want to date her. She should understand.
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Politely communicate to the person that you are flattered but not interested in a romantic relationship due to differing sexual orientations. It's important to be respectful and clear about your boundaries.
Tell her that you're flattered but that you don't lean that way. Either she'll settle for friendship or she'll move on.