Long term alcohol use can lead to mouth and throat cancer. Also, high blood pressure and heart trouble, also sclerosis of the liver are some long term effects.
Regular alcohol consumption in moderation is associated with better health and longer life than abstaining.
It can give you dry skin, that's what it did to me.
The effects of alcohol ABUSE can include falling over a lot, being an idiot, massive hangover, plus loads of long term health issues. Moderate alcohol consumption is associated with better health and greater longevity than is abstaining from alcohol.
Alcohol usually has a temporarily toxic effect on the central nervous system. The effects of alcohol will usually be memory loss, slow movement and impaired judgment. Long term use of Alcohol will make these symptoms permanent.
liver
Long term use of Acetaminophen can effect your liver. More at link.
Brain Damage Malnutrition
There is no conclusive evidence of negative long term side effects associated with the use of marijuana. The euphoric effects of marijuana only last up to three hours.
Long term alcohol consumption can lead to memory problems, cognitive deficits, and a higher risk of developing neurological disorders such as dementia. Prolonged alcohol use can also lead to brain shrinkage and impair the brain's ability to function properly.
It makes you mentally high.. On long term use there are side effects..
Brain Damage Malnutrition