Zithromax, also known as azithromycin, is a new generating macrolide anti-biotic that blocks the 50-s ribosomal sub-unit, thus interfering with protein synthesis, also known as translation in bacteria. There is no data available from multi-center randomized placebo controlled clinical trials establishing any interaction between cannibis and zithromax.
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Only if it is legal to smoke it where you are without other drugs.
If so you need to check with your physician.
Marijuana has not yet been proven to have any negative side affects combined with other medications. Take it flow and see how you feel.