Not advised.
Only if you wanna blow your thumb off,get blind,or mess up your gun....The .22 LR's case is smaller in diameter,so when you pull the trigger the case is going to swell instantly to fit what is supposed to be a .22 Mag chamber,and then split,releasing a flash of hot gasses and case fragments straight at you and your guns chamber and bore.Firearm cartridges although small create a lot of pressure to push a bullet down a barrel,(Think of it as driving a rail road spike into a screw hole,its all about pressure)even the .22 LR is capable of pressures up to 5,000 psi...Dont Do It!!!!...You can however buy revolvers that have 2 cylinders(1 for .22lr and 1 for .22mag),that are interchangeable.Then you can beat the high ammo prices....
2. The .22 LR round will burst and unravel in a .22 magnum chamber nearly every time. It will fire a bullet downrange though and accuracy will be poor.
The gasses will exit the burst cartridge, usually harmlessly though that is not guaranteed, and it it not advised as above.
However there are sleeves that can safely convert a .22 magnum chamber to use a .22 Long Rifle cartridge with no problems. The sleeve fits around the .22 LR cartridge.
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