Can a 45 pistol kill a bear?

Answer 1

As said below. Bears have been killed with about every firearm made, HOWEVER, the .45 ACP does not have the energy to insure a quick, clean kill- and would be likely to get the shooter killed- by the bear.

Answer 2

A .45 pistol can only kill a bear by luck. Much more likely, it will only get the bear very angry.