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Izzie and Alex got married during her battle with cancer, and after her survival she left Alex after being fired from the hospital. Then she returned and tried to make amends and Alex refused. They signed divorce papers and parted ways. This was also the end of Izzie Stevens time on Grey's Anatomy.

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11y ago

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Izzie and Alex broke up in Grey's Anatomy because Izzie left Seattle and their marriage after a traumatic battle with cancer. Their relationship faced numerous challenges and they ultimately decided to part ways.

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10mo ago
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Q: Why did Izzie and Alex break in Grey's Anatomy?
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