Izzie and Alex got married during her battle with cancer, and after her survival she left Alex after being fired from the hospital. Then she returned and tried to make amends and Alex refused. They signed divorce papers and parted ways. This was also the end of Izzie Stevens time on Grey's Anatomy.
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Izzie and Alex broke up in Grey's Anatomy because Izzie left Seattle and their marriage after a traumatic battle with cancer. Their relationship faced numerous challenges and they ultimately decided to part ways.
If you mean who stars with Sandra Oh in Grey's Anatomy, here's the list. Ellen Pompeo - Meredith Patrick Depmsey - Derek Katherine Heigl - Izzie T.R. Knight - George Eric Dane - Mark Chandra Wilson - Bailey Justin Chambers - Alex Sara Ramirez - Callie Chyler Leigh - Lexi those are all of the current characters on grey's anatomy. some of the previous cast members include: Kate Walsh - Addison Isaiah Washington - Burke Brooke White - Erica Hahn
Izzy Stevens was terminated from her position at Seattle Grace Hospital due to unethical behavior involving a patient. She undermined hospital protocols by illegally obtaining a heart for her love interest, Denny Duquette, which ultimately led to her dismissal.
No, Izzie does flatline but she doesn't die. She comes back for one episode of season 6, but then is fired from Seatlly Grace hopital. Katherine Hiegl leaves the show because she wanted to be close with her family.
Season 5 of Grey's Anatomy ends with George O'Malley dying tragically from injuries sustained after getting hit by a bus. The final moments show the other characters grappling with his death and mourning his loss.
Izzy's love interest on Grey's Anatomy is Alex Karev. Their relationship has various ups and downs throughout the series.