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Izzie and Alex got married during her battle with cancer, and after her survival she left Alex after being fired from the hospital. Then she returned and tried to make amends and Alex refused. They signed divorce papers and parted ways. This was also the end of Izzie Stevens time on Grey's Anatomy.

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10y ago
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3mo ago

Izzie and Alex broke up in Grey's Anatomy because Izzie left Seattle and their marriage after a traumatic battle with cancer. Their relationship faced numerous challenges and they ultimately decided to part ways.

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Q: Why did Izzie and Alex break in Grey's Anatomy?
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Related questions

Who does Izzie marry on Grey's Anatomy?

Izzie marrys Alex Karev in the Sixth season, and then they divorce shortly after.


Is Izzie and Alex still married on Grey's Anatomy?

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Will Izzy and Alec get back together in season 7?

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