Dr. Preston Burke makes a very short return at the end of Season 10. He is the reason Cristina leaves Seattle (Grey Sloan) because he offers her his job to go to a better heart facility in Switzerland where she can continue her research of printing a fully functional heart.
He originally left the show after Cristina left him on the altar, but in real life he was kicked off because he made deragatory remarks about George O'Malley's actor T.R. Knight being gay.
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Izzy was fired on Grey's Anatomy because she made the unethical decision to give a heart transplant to a patient who wasn't eligible according to the hospital's policies. This led to her termination from the hospital.
For season 6 of Grey's Anatomy, the main cast members returning include Ellen Pompeo as Meredith Grey, Sandra Oh as Cristina Yang, Justin Chambers as Alex Karev, Chandra Wilson as Miranda Bailey, James Pickens Jr. as Richard Webber, and Patrick Dempsey as Derek Shepherd.
Grey's Anatomy - 2005 Take It Back 10-13 is rated/received certificates of: Netherlands:12 USA:TV-14
No, Izzie does flatline but she doesn't die. She comes back for one episode of season 6, but then is fired from Seatlly Grace hopital. Katherine Hiegl leaves the show because she wanted to be close with her family.