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Phosphorylase adds the Phosphate group to substrate, but phosphatase takes off the Phosphate group from the substrate. the function of phosphorylase can be considered as same as kinase.

they are all playing key roles in the cellular signalling transduction via control the phosphorylation, the phosphatase can be the negative or positive regulator for different pathways. e.g. PTP1B dephosphorylates the JAK2 to suppress leptin in the hypothalamus that contribute to weight gain.

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Phosphorylase is an enzyme that adds a phosphate group to a molecule, typically to activate it. Phosphatase is an enzyme that removes a phosphate group from a molecule, usually to deactivate it or regulate its activity. Essentially, phosphorylase adds a phosphate group while phosphatase removes a phosphate group.

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Q: What is the difference between phosphorylase and phosphatase?
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