due to lack of b12
No HCl and intrinsic factor = pernicious anemia
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Inadequate intrinsic factor is associated with vitamin B12 deficiency, as intrinsic factor is necessary for the absorption of this essential nutrient in the gut. Vitamin B12 deficiency can lead to symptoms such as anemia, fatigue, and neurological problems. It is commonly seen in individuals with pernicious anemia or autoimmune conditions affecting the stomach lining.
Intrinsic factor, a protein produced in the stomach, helps in the absorption of vitamin B12. This vitamin is crucial for red blood cell formation and neurological function. Absorption of vitamin B12 occurs in the small intestine, where it binds to intrinsic factor for transport into the bloodstream.
The protein secreted by the stomach that is necessary for the absorption of vitamin B12 is called intrinsic factor. Intrinsic factor binds to vitamin B12 in the small intestine, allowing for its absorption into the bloodstream. Without intrinsic factor, vitamin B12 cannot be effectively absorbed and can lead to a deficiency.
Oral administration of vitamin B12 is not effective for pernicious anemia because the condition involves a lack of intrinsic factor, which is needed for the absorption of B12 in the intestines. Without intrinsic factor, the intestines are unable to absorb enough B12 from oral supplements to treat the deficiency. In such cases, B12 injections are typically used for effective treatment.
intrinsic factor
Factor VIII is crucial in the intrinsic pathway of the blood coagulation system. It helps in the activation of factor X, which is a key step in the formation of a blood clot. Without factor VIII, this pathway would be impaired, leading to difficulties in clot formation.