It is called intrinsic factor, which enables the absorption of B12. Intrinsic factor is found in the parietal cells (mucosa cells) of the stomach lining.
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Intrinsic factor, a protein produced in the stomach, helps in the absorption of vitamin B12. This vitamin is crucial for red blood cell formation and neurological function. Absorption of vitamin B12 occurs in the small intestine, where it binds to intrinsic factor for transport into the bloodstream.
The protein secreted by the stomach that is necessary for the absorption of vitamin B12 is called intrinsic factor. Intrinsic factor binds to vitamin B12 in the small intestine, allowing for its absorption into the bloodstream. Without intrinsic factor, vitamin B12 cannot be effectively absorbed and can lead to a deficiency.
Vitamins B6, B12, and C play important roles in helping the body utilize protein. Vitamin B6 helps in the metabolism of amino acids, vitamin B12 aids in the synthesis of proteins, and vitamin C helps in the absorption of iron which is needed for protein production.
Oral administration of vitamin B12 is not effective for pernicious anemia because the condition involves a lack of intrinsic factor, which is needed for the absorption of B12 in the intestines. Without intrinsic factor, the intestines are unable to absorb enough B12 from oral supplements to treat the deficiency. In such cases, B12 injections are typically used for effective treatment.
Individuals following a vegan or vegetarian diet, older adults, and those with certain gastrointestinal conditions (such as pernicious anemia or celiac disease) are most likely to be vitamin B12 deficient. Additionally, individuals who have had weight loss surgery or take certain medications that interfere with vitamin B12 absorption may also be at risk.
The function of the ileum is mainly to absorb vitamin B12 and bile salts and whatever products of digestion were not absorbed by the jejunum.