Your grandfather's brother's granddaughter is your second cousin.
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You and your great grandfather's brother's daughter's daughter are second cousins, once removed, to each other.
He would be your great-great uncle.
Your grandfather's uncle is your great great uncle. Your grandfather's brother would be your great uncle
Step-great-granddaughter
Tun Dr. Mahathir's granddaughter is named Shaista Mayada Sosrowardoyo
If you really need a relationship term, use granddaughter-in-law. Most people would merely say "my grandson's wife."