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Pernicious anemia results from a combination of lack of intrinsic factor and?
atropic gastritis
What is perniciousness?
This is anaemia (lowered blood haemoglobin) due to a lack of vitamin B12 absorbed from the intestinal tract, due to a lack of intrinsic factor usually. This can be due to auto antibodies against the cells that produce intrinsic factor, stomach ulcers crowding out the cells that produce intrinsic factor, a hereditary lack of intrinsic factor or the after effects of surgery, illness or fish tapeworm. This gives a macrocytic anaemia. Pernicious anemia is an autoimmune disease that renders the person unable to absorb sufficient Vitamin B-12. Eventually the person becomes Vitamin B-12 deficient and must be treated. Prior to the availability of treatment persons died from the disease, hence the name pernicious. It is critical that treatment be obtained as soon as possible. You can find more information at the following website: www.pernicious-anaemia-society.org
What is pernicious anemia and it's symptoms?
This is anaemia (lowered blood haemoglobin) due to a lack of vitamin B12 absorbed from the intestinal tract, due to a lack of intrinsic factor usually. This can be due to auto antibodies against the cells that produce intrinsic factor, stomach ulcers crowding out the cells that produce intrinsic factor, a hereditary lack of intrinsic factor or the after effects of surgery, illness or fish tapeworm. This gives a macrocytic anaemia. Pernicious anemia is an autoimmune disease that renders the person unable to absorb sufficient Vitamin B-12. Eventually the person becomes Vitamin B-12 deficient and must be treated. Prior to the availability of treatment persons died from the disease, hence the name pernicious. It is critical that treatment be obtained as soon as possible. You can find more information at the following website: www.pernicious-anaemia-society.org
Inadequate intrinsic factor is associated with?
Inadequate intrinsic factor is associated with vitamin B12 deficiency, as intrinsic factor is necessary for the absorption of this essential nutrient in the gut. Vitamin B12 deficiency can lead to symptoms such as anemia, fatigue, and neurological problems. It is commonly seen in individuals with pernicious anemia or autoimmune conditions affecting the stomach lining.
A hereditary lack of melanin results in a discorder called?
albinism, a hereditary disorder that affects melanin production, there is a lack of pigment in the skin, hair, and eyes. "Memmler's The Human Body in Health and Disease 11th edition"
A factor that results in the decay of long-term memory is?
lack of use
What will the Lack of intrinsic factor result in?
A lack of intrinsic factor will result in impaired absorption of vitamin B12 in the intestines, leading to a condition called pernicious anemia. This can cause symptoms such as fatigue, weakness, and neurological issues if left untreated. Treatment often involves regular B12 injections to bypass the absorption issue.
Lack of intrinsic factor?
DefinitionIntrinsic factor is a natural substance normally found in the stomach. You need this substance to absorb vitamin B12 from foods.A lack of intrinsic factor leads to pernicious anemia and vitamin B12 deficiency, which can cause anemia and brain and nervous system (neurological) problems.Alternative NamesIntrinsic factor - lack ofCauses, incidence, and risk factorsBabies that are born without intrinsic factor cannot properly absorb vitamin B12 starting around age 6 months. Children who have the juvenile type of lack of intrinsic factor tend to show signs and symptoms after age 10.Older adults get pernicious anemia, which is caused by a lack of intrinsic factor production. This is usually due to an autoimmune disease that causes the stomach lining to waste away (atrophy). The stomach lining is where intrinsic factor is usually made.ReferencesAntony AC. Megaloblastic anemias. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingstone; 2008:chap 39.
What is important function of the intrinsic factor found in the stomach?
the b12 intrinsic factor produced by the parietal cells in the stomach (parietal cells also produce HCL, the acid that dissolves food and converts pesinogen (secreted by the chief cells). B12 is necessary for carbohydrate, protein and fat to be used by the boy but most importantly b12 is necessary for all cells in the body (especially red blood cells) to work properly; if deficient in the body the person may develop pernicious anemia (due to the excessive destruction of immature blood cells or the lack of their production due to a lack of vitamin b12) as well as other problems such as problems with the nervous system sue to the fact that b12 is used to cover nerve cells thus the lack of vitamin b12 can also get to the brain and in kill the person. The intrinsic factor secreted by the stomach's parietal cells is used to absorb vitamin b12 as the body cannot absorb it on its own. As a result the intrinsic factor is essential for life as there will be vitamin vb12 deficiency if there is no intrinsic factor to help the boy absorb it. Another important fact is that vitamin b12 is absorbed( with the help of the intrinsic factor) by cubulin receptors in the ileum of the small intestine.
Why oral administration of vitamin B12 not effective as a treatment of pernicious anemia?
Oral administration of vitamin B12 is not effective for pernicious anemia because the condition involves a lack of intrinsic factor, which is needed for the absorption of B12 in the intestines. Without intrinsic factor, the intestines are unable to absorb enough B12 from oral supplements to treat the deficiency. In such cases, B12 injections are typically used for effective treatment.
A hereditary bleeding disorder that results from lack of clotting factors?
Hemophilia is a hereditary bleeding disorder where a person lacks certain clotting factors, such as Factor VIII or Factor IX. This can result in prolonged bleeding and difficulty forming blood clots, leading to potential serious complications if not managed properly. Treatment often involves replacing the missing clotting factors through infusions.
What is pernicious anemea?
This is anaemia (lowered blood haemoglobin) due to a lack of vitamin B12 absorbed from the intestinal tract, due to a lack of intrinsic factor usually. This can be due to auto antibodies against the cells that produce intrinsic factor, stomach ulcers crowding out the cells that produce intrinsic factor, a hereditary lack of intrinsic factor or the after effects of surgery, illness or fish tapeworm. This gives a macrocytic anaemia. Pernicious anemia is an autoimmune disease that renders the person unable to absorb sufficient Vitamin B-12. Eventually the person becomes Vitamin B-12 deficient and must be treated. Prior to the availability of treatment persons died from the disease, hence the name pernicious. It is critical that treatment be obtained as soon as possible. You can find more information at the following website: www.pernicious-anaemia-society.org
