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Anonymous
Your sister's son's son is her grandson.
Your sister's son and your brother's son are first cousins.
Your sister's grandson and your brother's son are first cousins, once removed.
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Are you male or female?
Male: great uncle
Female: great aunt
He would be your step-brother, or half-brother.
He would be your nephew if he's a boy, and your niece if they're a girl.
Uncle or Auntie.
Uncle / Aunt to nephew
you are grandfather/mother