Well, I have been on Nexium for 3 years now. It's the only medication that would work. Considering I have acid reflux disease and have had 2 ulcers. I tried Prilosec before, some people tell me it worked great for them, for me, i took it about 3 days and it made my stomach feel worse! Nexium is the best medicine by far that I've found to work...
Nexium is simply another isomer of Prilosec, or a chemical brother to it. It has exactly the same actions, since it is a mirror image of the molecule.
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The difference is that the names are different as one is a trade name and the other is a generic name.
The other difference is in the pricing. Prilosec is a brand name while Omerprazole is a usually cheaper generic.