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Actualy white blood cells release histamine.
Basophils release histamine in response to the presence of microorganisms.
Mast cells and basophils release histamine. When histamine is released, it causes blood vessels to dilate, which can lead to symptoms such as redness and swelling (inflammation), increased mucus production, and smooth muscle contraction, resulting in symptoms like itching and bronchoconstriction.
Histamine release can be stimulated by various triggers such as allergens, physical injury, stress, and certain types of drugs. When the immune system detects these triggers, it releases histamine as part of the inflammatory response.
Histamine is released by basophils and mast cells in near by connective tissue which is an immune response to foreign pathogens.
Basophils primarily release histamine and other pro-inflammatory molecules in response to allergens. They do not secrete hormones like the endocrine glands, such as the pituitary gland, which releases hormones like growth hormone or thyroid-stimulating hormone.
Mast cells are the primary cells that produce and release histamine. Histamine is stored in granules within mast cells and is released in response to allergens and other triggers, leading to symptoms of allergy such as itching, sneezing, and swelling.
Histamine and heparin
Usually itching is caused by the release of histamine as part of an immune response, either an inappropriate response to proteins in the environment (i.e. allergies) or to a parasitic infection.
Mast cells release chemicals known as histamine, cytokines, and proteases in response to allergens or injury, which can contribute to allergic reactions and inflammation.
Release of histamine causes dilation of blood vessels, increased vascular permeability, and smooth muscle contraction. This can result in symptoms such as itching, redness, swelling, and bronchoconstriction depending on the location of release and the receptors it activates.
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