histamine is produced by basophils and by mast cells found in nearby connective tissues. It is found in virtually all animal body cells.[
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Mast cells are the primary cells that produce and release histamine. Histamine is stored in granules within mast cells and is released in response to allergens and other triggers, leading to symptoms of allergy such as itching, sneezing, and swelling.
Eusonophils and Basophils produce histamine.Also mast cells produce histamine.
Mast cells are the connective tissue cells that produce histamine in response to various stimuli, such as allergens or injury. Histamine is a key mediator of inflammation and allergic responses in the body.
Mast cells and basophils produce the histamine, which antihistamines block. The cytoplasm of a mast cell is filled with granules containing histamine and heparin. Histamine, released after injury or infection, stimulates local inflamation. People often take antihistamines to reduce cold symptoms. Basophils, blood cells that enter damaged tissues and enhance the inflammation process, also contain granules of histamine and haparin.
Chief cells in the stomach work with parietal cells to produce gastric acid. Chief cells secrete pepsinogen, which is activated by the acid produced by parietal cells to form pepsin, an enzyme that helps break down proteins. Together, parietal and chief cells contribute to the digestive process in the stomach.
Mast cells are the cells of the dermis that release histamine and play a crucial role in hypersensitivity reactions of the skin. Histamine release from mast cells can trigger allergic responses and inflammation in the skin, leading to symptoms like redness, itching, and swelling.