Antihistamines are medications used to relieve symptoms of Allergies, such as sneezing, runny nose, itchy eyes, and hives. They work by blocking the action of histamine, a substance in the body that triggers allergic reactions. Antihistamines can also be used to treat symptoms of the common cold and some types of nausea. There are two main types: first-generation, which may cause drowsiness, and second-generation, which are less sedating.