It really depends on 3 factors:
-WHAT'S being biopsied
-WHERE'S it's being biopsied from
-SIZE of material being biopsied
I had a biopsy done on my arm. My doctor extracted a roughly 1 inch square of skin; the entire procedure only took 15 minutes.
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The procedure takes 30-45 minutes, although the biopsy needle itself remains in the pleura for less than one minute.