It is not possible. The movies and TV have made people think that you can get conked on the head, fall down unconscious, and jump back up in a few minutes with no problems, but that's just wrong. If you are hit hard enough to lose consciousness, your brain gets bruised. If you don't hit the head exactly right, you could even crack or break the skull. The person will wake up with a severe headache at the very least, and most likely will have a concussion, memory loss, and maybe permanent damage. Don't try this one at home!
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Here's the thing; You can't KO someone without the possibility of hurting them. This is because to KO someone you have to make the brain hit hard on the inside of the skull, cut off flow to the brain, or hit nerve's/arteries. Hope this helps!
Force them to run eight miles, then feed then a very large meal full of protein and sugar, then tell them to go lie down.
try injecting them with something, like they do in hospital. either that or gas them with something.