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Prodrugs are pharmacologically inactive derivatives of active drugs. They are designed to maximize the amount of active drug that reaches its site of action, through manipulation of the physicochemical, biopharmaceutical or pharmacokinetic properties of the drug. Drugs are sometimes divided into "hard drugs " and "soft drugs". Hard drugs are "non-metabolizable drugs" or drugs which are metabolized to biologically active metabolites. The metabolites of hard drugs are frequently toxic oxidation products. Soft drugs are drugs which are characterized by a predictable and controllable in vivo destruction to non-toxic products after they have achieved their therapeutic role. But some Pharmaceutical company like Vitality has developed a new class of cannabinoid prodrugs, known as cannabosides, which upon ingestion can enable the selective delivery of THC and cannabidiol to the gastrointestinal tract.
What else can I help you with?
When does a prodrug become active?
A prodrug becomes active when it is metabolized into its active form by the body's enzymes. This usually occurs after the prodrug is administered and travels to the site where it is converted into the active drug. Once activated, it can exert its therapeutic effect.
What is prodrug?
A prodrug is a drug that is inactive when you take it (when it is administered), but then becomes active once your body starts to break it down (usually through metabolism). Stimulant simply refers to a class of drug. The opposite would be a non-stimulant. However, it is a different adjective describing the drug and is not part of "prodrug". That is, to be clear, the drug you're looking at is both a stimulant and a prodrug.
Why captopril is uses as a prodrug?
Captopril is not used as a prodrug. It is an active drug itself, classified as an angiotensin-converting enzyme (ACE) inhibitor used to treat hypertension and heart failure by blocking the conversion of angiotensin I to angiotensin II.
Can you smoke Vyvanse?
No; Vyvanse is a prodrug that requires to be swallowed for the drug (dextroamphetamine) to become active. Smoking will produce no psychoactive effects and is dangerous for your health.
Is cefopodoxime a pro drug?
cefpodoxime proxetil is a prodrug that is de-esterified in the GI tract. It becomes cefpodoxime free acid which is the active metabolite.
What are the benefits of a prodrug?
A prodrug actually has several biopharmaceutical benifits. First of all, it is important to understand the definition of a prodrug. A prodrug is a drug that is taken inactive, and through natural metabolic processes becomes active. One benifit is that a prodrug formulation actually increases the bioavailability of the drug. This means that if a drug is poorly absorbed by the body, a prodrug formulation of it can actually increase the amount of drug brought into the circulatory system (By making less polar/ionized). Next, this formulation can act as a vehicle to bring the drugs to specific areas of the body for usage. Drugs that need to pass the blood brain barrier for CNS affects can use a very lipid soluble vehicle bound to it to allow it to cross the barrier. Once the drugs gets to its target site, it is broken down by specific metabolic processes that present the active drug. Furthermore, a mutual prodrug is when both componants give pharmacotherapeutic affect. The Vigabatrin (GABA deaminase inhibitor), GABA (inhibbitory neurotransmitter), Fatty acyl ester (very lipid soluble) prodrug combination is a mutual prodrug in which the Vehicle takes the drug to the brain, the vigabatrin blocks the breakdown of GABA, and GABA is released. This prodrug is a treatment of Parkinsons disease as it increases the inhibition of the tremors and erratic movements associated with it. Finally, it also gives less side effects. Because of increased specificity (due to the fact only certain metabolic processes break down the prodrug, releasing its active componants at specific sites) their are a reduced amount of side effects. Hope this helps
What is a compound word that includes drug?
drugstore prodrug
Which drug is a prodrug that is activated by colonic bacteria when given orally?
One example of a drug that is a prodrug activated by colonic bacteria when given orally is sulfasalazine. In the colon, bacteria cleave the molecule, releasing the active components, sulfapyridine and 5-aminosalicylic acid, which are then absorbed and exert their therapeutic effects in conditions such as ulcerative colitis and Crohn's disease.
What are the disadvantages a prodrug?
Some disadvantages of prodrugs include potential variability in conversion to the active drug due to individual differences in metabolism, the risk of inactive metabolites causing toxicity, and the need for additional steps in drug processing which can complicate drug development and regulation.
Will vyvance show up on a drug screen as an amphetamine?
Yes. It is a prodrug of an amphetamine.
What is the difference between Atorvastin and Lipitor?
There is no difference between Atorvastin and Lipitor. They are the name drug used to control high cholesterol or hypercholesteraemia. Atovastin is the active drug used in Lipitor to gain the desired effect, Lipitor is just a trade name that a drug company uses to sell or identify the drug. Generic : Atorvastin Trade : Lipitor
How do prodrug work?
Prodrugs are big reversible derivatives of drug molecules that undergo an enzymatic and/or chemical transformation in vivo to release the active parent drug, which can then exert the desired pharmacological effect. In both drug discovery and development, prodrugs have become an established tool for improving physicochemical, biopharmaceutical or pharmacokinetic properties of pharmacologically active agents. About 5-7% of drugs approved worldwide can be classified as prodrugs, and the implementation of a prodrug approach in the early stages of drug discovery is a growing trend. Thanks to some Pharmaceutical company's, they gave their ability to rapidly create proprietary prodrug versions of each these cannabinoids, they stand to benefit from emerging data and increasing recognition from the medical community of the potent pain relief and anti-inflammatory effects of cannabinoids.
