0
A prodrug is a drug that is inactive when you take it (when it is administered), but then becomes active once your body starts to break it down (usually through metabolism). Stimulant simply refers to a class of drug. The opposite would be a non-stimulant. However, it is a different adjective describing the drug and is not part of "prodrug". That is, to be clear, the drug you're looking at is both a stimulant and a prodrug.
A prodrug is a pharmacological substance (drug) that is administered in an inactive (or significantly less active) form. Once administered, the prodrug is metabolised in vivo into an active metabolite. The rationale behind the use of a prodrug is generally for absorption, distribution, metabolism, and excretion (ADME) optimization. Prodrugs are usually designed to improve oral bioavailability, with poor absorption from the gastrointestinal tract usually being the limiting factor.
Add your answer:
Earn +20 pts
What prodrug is activated by colonic bacteria when given orally?
Balsalazide-azo-bonded prodrug, activated by bacteria in the colon
When does a prodrug become active?
A prodrug becomes active when it is metabolized into its active form by the body's enzymes. This usually occurs after the prodrug is administered and travels to the site where it is converted into the active drug. Once activated, it can exert its therapeutic effect.
What is methyl phenobarbital?
Prodrug for Phenobarbital.
What is a compound word that includes drug?
drugstore prodrug
How can the hydrolysis rate of prodrugs be accelerated?
If the base hydrolysis mechanism is important, an electron withdrawing group can be attached to the prodrug. If the acid hydrolysis mechanism is important, an electron donating group can be attacked to the prodrug.
What are the benefits of a prodrug?
A prodrug actually has several biopharmaceutical benifits. First of all, it is important to understand the definition of a prodrug. A prodrug is a drug that is taken inactive, and through natural metabolic processes becomes active. One benifit is that a prodrug formulation actually increases the bioavailability of the drug. This means that if a drug is poorly absorbed by the body, a prodrug formulation of it can actually increase the amount of drug brought into the circulatory system (By making less polar/ionized). Next, this formulation can act as a vehicle to bring the drugs to specific areas of the body for usage. Drugs that need to pass the blood brain barrier for CNS affects can use a very lipid soluble vehicle bound to it to allow it to cross the barrier. Once the drugs gets to its target site, it is broken down by specific metabolic processes that present the active drug. Furthermore, a mutual prodrug is when both componants give pharmacotherapeutic affect. The Vigabatrin (GABA deaminase inhibitor), GABA (inhibbitory neurotransmitter), Fatty acyl ester (very lipid soluble) prodrug combination is a mutual prodrug in which the Vehicle takes the drug to the brain, the vigabatrin blocks the breakdown of GABA, and GABA is released. This prodrug is a treatment of Parkinsons disease as it increases the inhibition of the tremors and erratic movements associated with it. Finally, it also gives less side effects. Because of increased specificity (due to the fact only certain metabolic processes break down the prodrug, releasing its active componants at specific sites) their are a reduced amount of side effects. Hope this helps
Will vyvance show up on a drug screen as an amphetamine?
Yes. It is a prodrug of an amphetamine.
Why captopril is uses as a prodrug?
Captopril is not used as a prodrug. It is an active drug itself, classified as an angiotensin-converting enzyme (ACE) inhibitor used to treat hypertension and heart failure by blocking the conversion of angiotensin I to angiotensin II.
What are the different types of carrier-linked prodrug?
The different types of carrier-linked prodrugs are bipartite, tripartite, and mutual. Bipartite structures consist of a carrier linked to a prodrug. Tripartite structues have a carrier linked to a drug via a linker. Mutual structures have two drugs linked to each other.
What is Psilocybin?
Psilocybin is a prodrug found in psilocybe (magic) mushrooms (along with psilocin and baeocystin). It is metabolized (dephosphorylated) into psilocin which the actual psychoactive.
Which drug is a prodrug that is activated by colonic bacteria when given orally?
One example of a drug that is a prodrug activated by colonic bacteria when given orally is sulfasalazine. In the colon, bacteria cleave the molecule, releasing the active components, sulfapyridine and 5-aminosalicylic acid, which are then absorbed and exert their therapeutic effects in conditions such as ulcerative colitis and Crohn's disease.
Is cefopodoxime a pro drug?
cefpodoxime proxetil is a prodrug that is de-esterified in the GI tract. It becomes cefpodoxime free acid which is the active metabolite.
