yes
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for the XBox 360, all guitar hero guitars can work in any direction
Yes they are =)
No it isn't.
Yes, the games are backwards compatible with the controllers. However, the old controllers can not be used with the Xbox One, or PS4.
Yes, on Xbox 360 all Guitar Hero world tour, Rockband, guitar hero 3 games are definitely cross compatible with instruments (obviously not with using the durms on guitar hero 3) and more then likely guitar hero 2.