myepets.com Was Shut Down Because The Ratings Of The Product - The Dogs - Were Too Low And The Website Had Too Many Issues.
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Your game shuts down when someone (usually the Admins or the Owner) decide to shut it down for what ever reason they though fit. Also there are scripts that can shut it down or people can hack and shut it down.
It was temporarily shut down to protest SOPA and PIPA.
Yes the me2 universe website is shut down.
Yes. It has been shut down as of June 7, 2013.
Nothing Toxic has been shut down since 2011.