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Since HeartGold and SoulSilver are part of the same pair of games, there are only a handful of differences between them, though probably the most noticeable are the version-exclusive Pokémon.
It's all a matter of personal preference.
http://bulbapedia.bulbagarden.net/wiki/Pokémon_HeartGold_and_SoulSilver_Versions
Well Exclusive Pokemon for Heart Gold are Mankey, Primape, Growlithe, Arcanine, Spinarak, Ariados, Gligar, Mantine, Phanpy, Donphan, Sabelye, Baltoy, Claydol, Kyorge, Mantyke and Gliscor.
Exclusive Pokemon For Soul Silver are Vulpix, Ninetales, Meowth, Persian, Ladiba, Ledian, Teddiursa, Ursaring, Delibird, Scarmory, Mawile, Gulpin, Swalot and Groudon.
There You Go! =D
The card key in Pokemon Heartgold and Soulsilver is located in the Goldenrod Underground.
The Quick claw is located in the National Park in Pokemon Heartgold and Soulsilver.
You can't. You need to get Heatran from Pokemon Diamond, Pearl and Platinum and then trade to heartgold and soulsilver.
In HeartGold and SoulSilver, she does not battle you - which might be one of the reasons why she doesn't have a starter pokemon. Instead, she has a Marill.
The only way to get a gligar in pokemon soulsilver is to trade with pokemon heartgold.