The Pokemon Lab is located on Cinnabar Island, west of the Pokemon Center.
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In the game Pokemon Yellow you have to beat the leader of gym seven in order to win the Volcano Badge. The leader of this gym is named Blaine and he specializes in fire type Pokemon. To enter this gym you first have to get the secret key. This key is located in the building across from the lab.
Professor Oak's official lab is situated in Pallet Town, Kanto [Pokemon Red, Blue, Green, Yellow, FireRed and LeafGreen]. He does visit the protagonist of the subsequent Pokemon games, but he has no other lab of his own. In Pokemon Gold and Silver (Johto), Oak can be found on Route 30 in a small house. In Pokemon Diamond and Pearl (Sinnoh), Oak has a small house towards the South of Eterna City.
No. They were made after Pokemon Yellow.
1st city