I would definitely say the magician is the best one to start the game with because all you have to do is use magic to kill the enemy. Starting with that class makes your life so much easier.
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undead
the best enchantment for healer class is at the lair
fisherman
ninja
there is no best class for two worlds 2 multiplayer everybody has there own unique character and there character has variety of skills and spells of which can not be put into a particular class. Your class for multiplayer is what you make it!