This is my opinion. If I were you, I would choose the secret den located to the east of the map. To find it, all you have to do is follow the river to the end of the map, then go up the small hill on the south side of the river, and you should find it. If you still can find it, use your scent vision, because there is a carcass right beside the den.
This den is right beside a carcass, a river, and it has a great view!
Now, if you are looking for a den that you can use in 1 player, try the bison den. It has many carcasses around, easy to spot predators, and also it is the closest to the point you have to travel, to beat the game.
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The secret den known as Slough Creek den is between Slough Creek and Bison Peak den in the hills. Regards, Lunaressa WolfQuest
The second quest in WolfQuest is where you and your mate look for a den, mark your territory, and protect and raise your pups.
your opion but i think saddle meadows is the safest
bison peak
by getting your pups to the summer den